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Clinical studies consistently report elevated circulating and central levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), in patients with major depressive disorder, with cytokine concentrations often correlating with symptom severity, illness chronicity, and treatment resistance (30, 32)

Methods of Glutathione Administration: Glutathione can be administered in several ways, including: Oral Supplements: Available in pill or capsule form, oral glutathione is a convenient option